MolNFT v1 · #114142 · protein
Structure of a flagellar type III secretion chaperone, flgn
5B3D · Flagella synthesis protein flgn: “Structure of a flagellar type III secretion chaperone, flgn”. X-ray diffraction, 5 pockets (best druggability 0.64). MolNFT v1 #114142 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5B3D
- Type
- protein
- Length
- 454 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Flagella synthesis protein flgn
- UniProt
- P0A1J7
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Flagella synthesis protein flgn | protein | 114 | 81% helix, 0% strand | P0A1J7 |
| B | Flagella synthesis protein flgn | protein | 117 | 79% helix, 0% strand | P0A1J7 |
| D | Flagella synthesis protein flgn | protein | 109 | 83% helix, 0% strand | P0A1J7 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.64 | 0.87 | 26 | empty |
| 2 | 86 | 0.50 | 0.83 | 20 | empty |
| 3 | 72 | 0.44 | 0.81 | 16 | empty |
| 4 | 66 | 0.43 | 0.82 | 18 | empty |
| 5 | 87 | 0.36 | 0.75 | 17 | empty |
Interfaces
6 interfaces between chains.
- A–B · 4239 Ų buried · 42 hydrogen bonds · protein-protein
- C–D · 4031 Ų buried · 37 hydrogen bonds · protein-protein
- B–C · 403 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 219 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 217 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 5B3D · Structure of a flagellar type III secretion chaperone, FlgN · the same entry in another collection · chain D against D, TM-score 1.00
- P0A1J7 · AlphaFold monomer V2.0 prediction for flagella synthesis protein flgn (P0A1J7) · a predicted model of the same protein · chain C against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A1J7
- Elsewhere: RCSB PDB 5B3D · PDBe 5B3D · UniProt P0A1J7
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