MolNFT v1 · #114049 · protein
Crystal structure of human leukocyte cell-derived chemotaxin 2
5B0H · Leukocyte cell-derived chemotaxin-2: “Crystal structure of human leukocyte cell-derived chemotaxin 2”. X-ray diffraction, 2 ligands (ZN, SO4), 4 pockets (best druggability 0.56). MolNFT v1 #114049 on GenesisL1: 3D structure, binding…
- PDB
- 5B0H
- Type
- protein
- Length
- 266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukocyte cell-derived chemotaxin-2
- UniProt
- O14960
- Ligands
- ZN, SO4
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Leukocyte cell-derived chemotaxin-2 | protein | 133 | 5% helix, 36% strand | O14960 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 254 | 0.56 | 0.78 | 31 | SO4 |
| 2 | 127 | 0.43 | 0.76 | 19 | empty |
| 3 | 134 | 0.43 | 0.76 | 18 | empty |
| 4 | 50 | 0.24 | 0.72 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 445 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 5B0H · Crystal structure of human leukocyte cell-derived chemotaxin 2 · the same entry in another collection · chain A against A, TM-score 1.00
- O14960 · AlphaFold monomer V2.0 prediction for leukocyte cell-derived chemotaxin-2 (O14960) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14960
- Elsewhere: RCSB PDB 5B0H · PDBe 5B0H · UniProt O14960
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