MolNFT v1 · #113988 · protein

Crystal structure of a bacterial homologue of iron transporter ferroportin in inward-facing state

5AYO · Solute carrier family 39 (iron-regulated transporter): “Crystal structure of a bacterial homologue of iron transporter ferroportin in inward-facing state”. X-ray diffraction, 2 ligands (ZN, K), 2 pockets (best druggability 0.76).…

PDB: 5AYO
Type: protein
Length: 406 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Solute carrier family 39 (iron-regulated transporter)
UniProt: Q6MLJ0
Ligands: ZN, K
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Solute carrier family 39 (iron-regulated transporter)	protein	406	79% helix, 0% strand	Q6MLJ0

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A
K · Potassium ion · metal · chains A
OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1142	0.76	0.78	92	empty
2	66	0.40	0.80	16	empty

Compared structures

5AYO · Crystal structure of a bacterial homologue of iron transporter ferroportin in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6MLJ0
Elsewhere: RCSB PDB 5AYO · PDBe 5AYO · UniProt Q6MLJ0

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