MolNFT v1 · #113955 · protein
Crystal structure of THG1 like protein (tlp)
5AXK · TRNA(HIS)-5'-guanylyltransferase (THG1) like protein: “Crystal structure of THG1 like protein (tlp)”. X-ray diffraction, 2 pockets (best druggability 0.68). MolNFT v1 #113955 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5AXK
- Type
- protein
- Length
- 459 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA(HIS)-5'-guanylyltransferase (THG1) like protein
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA(HIS)-5'-guanylyltransferase (THG1) like protein | protein | 220 | 49% helix, 16% strand | — |
| B | TRNA(HIS)-5'-guanylyltransferase (THG1) like protein | protein | 239 | 46% helix, 19% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 477 | 0.68 | 0.79 | 42 | GOL |
| 2 | 371 | 0.65 | 0.79 | 42 | GOL |
Interfaces
1 interface between chains.
- A–B · 2011 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 5AXK · Crystal structure of Thg1 like protein (TLP) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5AXK · PDBe 5AXK
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