MolNFT v1 · #113741 · protein

Crystal structure of pneumolysin deletion mutant DELTA146_147.

5AOF: “Crystal structure of pneumolysin deletion mutant DELTA146_147.”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #113741 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5AOF
Type: protein
Length: 488 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pneumolysin
UniProt: Q04IN8
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pneumolysin	protein	488	19% helix, 40% strand	Q04IN8

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	222	0.62	0.82	39	empty
2	80	0.48	0.83	21	empty
3	80	0.43	0.80	22	empty
4	132	0.37	0.73	22	empty

Compared structures

5AOF · Crystal structure of pneumolysin deletion mutant Delta146_147. · the same entry in another collection · chain A against A, TM-score 1.00
Q04IN8 · AlphaFold monomer V2.0 prediction for pneumolysin (Q04IN8) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04IN8
Elsewhere: RCSB PDB 5AOF · PDBe 5AOF · UniProt Q04IN8

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