MolNFT v1 · #11369 · protein
Brefeldin a esterase, a bacterial homologue of human hormone sensitive lipase
1JKM: “Brefeldin a esterase, a bacterial homologue of human hormone sensitive lipase”. X-ray diffraction, 10 pockets (best druggability 0.71). MolNFT v1 #11369 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1JKM
- Type
- protein
- Length
- 719 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Brefeldin a esterase
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Brefeldin a esterase | protein | 358 | 42% helix, 17% strand | — |
| B | Brefeldin a esterase | protein | 361 | 42% helix, 18% strand | — |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 502 | 0.71 | 0.81 | 68 | empty |
| 2 | 624 | 0.71 | 0.78 | 49 | empty |
| 3 | 244 | 0.70 | 0.85 | 35 | empty |
| 4 | 248 | 0.70 | 0.85 | 35 | empty |
| 5 | 138 | 0.67 | 0.89 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 1485 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 1JKM · Brefeldin a esterase, a bacterial homologue of human hormone sensitive lipase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1JKM · PDBe 1JKM
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.