MolNFT v1 · #113686 · protein

Crystal structure of SQT1

5AMS · Ribosome assembly protein SQT1: “Crystal structure of SQT1”. X-ray diffraction, 5 pockets (best druggability 0.72). MolNFT v1 #113686 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5AMS
Type: protein
Length: 771 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosome assembly protein SQT1
UniProt: P35184
Pockets: 5 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribosome assembly protein SQT1	protein	392	3% helix, 49% strand	P35184
B	Ribosome assembly protein SQT1	protein	379	3% helix, 51% strand	P35184

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1150	0.72	0.76	67	empty
2	1125	0.72	0.76	62	empty
3	87	0.36	0.76	20	empty
4	68	0.29	0.73	13	empty
5	58	0.28	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 456 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5AMS · Crystal structure of Sqt1 · the same entry in another collection · chain A against A, TM-score 1.00
P35184 · AlphaFold monomer V2.0 prediction for ribosome assembly protein SQT1 (P35184) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35184
Elsewhere: RCSB PDB 5AMS · PDBe 5AMS · UniProt P35184

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