MolNFT v1 · #113579 · protein
Crystal structure of a coiled-coil domain from human THAP11
5AJS · Thap domain-containing protein 11: “Crystal structure of a coiled-coil domain from human THAP11”. X-ray diffraction, 1 pocket (best druggability 0.27). MolNFT v1 #113579 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5AJS
- Type
- protein
- Length
- 250 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thap domain-containing protein 11
- UniProt
- Q96EK4
- Pockets
- 1 · best druggability 0.27
Structure
x-ray diffraction · 4 distinct chains · 92% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thap domain-containing protein 11 | protein | 63 | 94% helix, 0% strand | Q96EK4 |
| B | Thap domain-containing protein 11 | protein | 64 | 89% helix, 0% strand | Q96EK4 |
| C | Thap domain-containing protein 11 | protein | 61 | 93% helix, 0% strand | Q96EK4 |
| D | Thap domain-containing protein 11 | protein | 62 | 92% helix, 0% strand | Q96EK4 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.27 | 0.73 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1622 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 1490 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5AJS · Crystal structure of a coiled-coil domain from human THAP11 · the same entry in another collection · chain D against D, TM-score 1.00
- Q96EK4 · AlphaFold monomer V2.0 prediction for thap domain-containing protein 11 (Q96EK4) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96EK4
- Elsewhere: RCSB PDB 5AJS · PDBe 5AJS · UniProt Q96EK4
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