MolNFT v1 · #113536 · protein
NOT4 ring domain in complex with UBC4
5AIE · General negative regulator of transcription subunit 4: “NOT4 ring domain in complex with UBC4”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.42). MolNFT v1 #113536 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5AIE
- Type
- protein
- Length
- 204 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General negative regulator of transcription subunit 4; Ubiquitin-conjugating enzyme E2 4
- EC
- 6.3.2.19
- UniProt
- P34909, P15731
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General negative regulator of transcription subunit 4 | protein | 54 | 17% helix, 7% strand | P34909 |
| B | Ubiquitin-conjugating enzyme E2 4 (EC 6.3.2.19) | protein | 150 | 35% helix, 17% strand | P15731 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.42 | 0.76 | 26 | empty |
| 2 | 56 | 0.41 | 0.81 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 611 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5AIE · Not4 ring domain in complex with Ubc4 · the same entry in another collection · chain A against A, TM-score 1.00
- P15731 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 4 (P15731) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P34909 · AlphaFold monomer V2.0 prediction for general negative regulator of transcription subunit… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34909
- Every structure of UniProt P15731
- Elsewhere: RCSB PDB 5AIE · PDBe 5AIE · UniProt P34909 · UniProt P15731
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