MolNFT v1 · #113462 · protein

Crystal structure of leishmania major N-myristoyltransferase (nmt) with bound myristoyl-CoA and a thiazolidinone ligand

5AG6 · Glycylpeptide N-tetradecanoyltransferase: “Crystal structure of leishmania major N-myristoyltransferase (nmt) with bound myristoyl-CoA and a…”. X-ray diffraction, 2 ligands (5PE, MYA), 2 pockets (best druggability 0.80). MolNFT v1…

PDB: 5AG6
Type: protein
Length: 402 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycylpeptide N-tetradecanoyltransferase
EC: 2.3.1.97
UniProt: Q4Q5S8
Ligands: 5PE, MYA
Pockets: 2 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97)	protein	402	31% helix, 28% strand	Q4Q5S8

Ligands and binding sites

5PE · (2R)-2-(4-hydroxy-3-methoxyphenyl)-3-(pyridin-2-ylmethyl)-1,3-thiazolidin-4-one · ligand · chains A
MYA · Tetradecanoyl-coa · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	919	0.80	0.82	85	5PE, MYA
2	129	0.41	0.75	26	empty

Compared structures

5AG6 · Crystal structure of leishmania major N-myristoyltransferase (nmt) with bound… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4Q5S8
Elsewhere: RCSB PDB 5AG6 · PDBe 5AG6 · UniProt Q4Q5S8

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