MolNFT v1 · #113425 · protein
Crystal structure of candida albicans MEP2
5AF1: “Crystal structure of candida albicans MEP2”. X-ray diffraction, 7 pockets (best druggability 0.68). MolNFT v1 #113425 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5AF1
- Type
- protein
- Length
- 901 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MEP2
- UniProt
- Q59UP8
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MEP2 | protein | 450 | 65% helix, 1% strand | Q59UP8 |
| B | MEP2 | protein | 451 | 64% helix, 1% strand | Q59UP8 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 533 | 0.68 | 0.78 | 63 | empty |
| 2 | 345 | 0.64 | 0.80 | 51 | empty |
| 3 | 280 | 0.55 | 0.76 | 43 | empty |
| 4 | 164 | 0.48 | 0.77 | 31 | empty |
| 5 | 82 | 0.33 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 103 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5AF1 · Crystal structure of Candida albicans Mep2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q59UP8
- Elsewhere: RCSB PDB 5AF1 · PDBe 5AF1 · UniProt Q59UP8
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