MolNFT v1 · #113400 · protein
Crystal structure of human ncam domain 1
5AEA · Neural cell adhesion molecule 1: “Crystal structure of human ncam domain 1”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #113400 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5AEA
- Type
- protein
- Length
- 198 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neural cell adhesion molecule 1
- UniProt
- P13591
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neural cell adhesion molecule 1 | protein | 100 | 3% helix, 56% strand | P13591 |
| B | Neural cell adhesion molecule 1 | protein | 98 | 3% helix, 51% strand | P13591 |
Ligands and binding sites
- FLC · Citrate anion · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.47 | 0.78 | 20 | empty |
| 2 | 183 | 0.45 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 469 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13591
- Elsewhere: RCSB PDB 5AEA · PDBe 5AEA · UniProt P13591
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