MolNFT v1 · #113380 · protein

Crystal structure of the A.17 antibody Fab fragment - light chain S35R mutant

5ADP · Fab A.17: “Crystal structure of the A.17 antibody Fab fragment - light chain S35R mutant”. X-ray diffraction, 3 pockets (best druggability 0.64). MolNFT v1 #113380 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ADP
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab A.17
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab A.17	protein	211	9% helix, 52% strand	—
L	Fab A.17	protein	217	4% helix, 50% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	660	0.64	0.74	63	empty
2	121	0.48	0.79	26	empty
3	78	0.41	0.79	18	empty

Interfaces

1 interface between chains.

H–L · 1695 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

5ADP · Crystal structure of the A.17 antibody FAB fragment - Light chain S35R mutant · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5ADP · PDBe 5ADP

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