MolNFT v1 · #11334 · protein
E2 DNA-binding domain from bovine papillomavirus type 1
1JJH · Regulatory protein E2: “E2 DNA-binding domain from bovine papillomavirus type 1”. X-ray diffraction, 2 pockets (best druggability 0.66). MolNFT v1 #11334 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1JJH
- Type
- protein
- Length
- 228 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulatory protein E2
- UniProt
- P03122
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulatory protein E2 | protein | 77 | 35% helix, 36% strand | P03122 |
| B | Regulatory protein E2 | protein | 78 | 35% helix, 36% strand | P03122 |
| C | Regulatory protein E2 | protein | 73 | 37% helix, 29% strand | P03122 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.66 | 0.82 | 28 | empty |
| 2 | 171 | 0.52 | 0.78 | 25 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1121 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 382 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1JJH · E2 DNA-binding Domain from Bovine Papillomavirus Type 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03122
- Elsewhere: RCSB PDB 1JJH · PDBe 1JJH · UniProt P03122
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