Crystal structure of the riboflavin kinase module of FAD synthetase from corynebacterium ammoniagenes in complex with FMN and ADP (P 32 2 1)

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 33% strand (DSSP).

Ligands and binding sites

• FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
• ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
• MG · Magnesium ion · metal · 2 copies · chains A, B
• ZN · Zinc ion · metal · 2 copies · chains A, B
• SO4 · Sulfate ion · ion · 2 copies · chains A, B
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 487 Ų buried · 12 hydrogen bonds · protein-protein

Compared structures

• 5A8A · Crystal structure of the riboflavin kinase module of FAD synthetase from Corynebacterium… · the same entry in another collection · chain A against A, TM-score 1.00
• Q59263 · AlphaFold monomer V2.0 prediction for bifunctional riboflavin KINASE/FMN… · a predicted model of the same protein · chain B against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q59263
• Elsewhere: RCSB PDB 5A8A · PDBe 5A8A · UniProt Q59263