MolNFT v1 · #113190 · protein
The GH130 family of mannoside phosphorylases contains glycoside hydrolases that target beta-1,2 mannosidic linkages in candida mannan
5A7V · Putative glycosidase PH117-related: “The GH130 family of mannoside phosphorylases contains glycoside hydrolases that target beta-1,2 mannosidic…”. X-ray diffraction, 3 ligands (MAN, BMA, SO4), 7 pockets (best druggability 0.69).…
- PDB
- 5A7V
- Type
- protein
- Length
- 727 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative glycosidase PH117-related
- UniProt
- R7KJA6
- Ligands
- MAN, BMA, SO4
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative glycosidase PH117-related | protein | 368 | 4% helix, 43% strand | R7KJA6 |
| B | Putative glycosidase PH117-related | protein | 359 | 3% helix, 44% strand | R7KJA6 |
Ligands and binding sites
- MAN · alpha-D-mannopyranose · sugar · 4 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 10 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 529 | 0.69 | 0.79 | 62 | empty |
| 2 | 156 | 0.55 | 0.81 | 19 | BMA, MAN |
| 3 | 138 | 0.53 | 0.80 | 21 | BMA, MAN |
| 4 | 78 | 0.53 | 0.85 | 23 | empty |
| 5 | 77 | 0.50 | 0.84 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 769 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 5A7V · The GH130 family of mannoside phosphorylases contains glycoside hydrolases that target… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt R7KJA6
- Elsewhere: RCSB PDB 5A7V · PDBe 5A7V · UniProt R7KJA6
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