MolNFT v1 · #112994 · protein

Leishmania major N-myristoyltransferase in complex with a chlorophenyl 1,2,4-oxadiazole inhibitor.

5A27 · Glycylpeptide N-tetradecanoyltransferase: “Leishmania major N-myristoyltransferase in complex with a chlorophenyl 1,2,4-oxadiazole inhibitor.”. X-ray diffraction, 3 ligands (MYA, TUT, MG), 3 pockets (best druggability 0.80). MolNFT…

PDB: 5A27
Type: protein
Length: 411 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycylpeptide N-tetradecanoyltransferase
EC: 2.3.1.97
UniProt: Q4Q5S8
Ligands: MYA, TUT, MG
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97)	protein	411	32% helix, 27% strand	Q4Q5S8

Ligands and binding sites

MYA · Tetradecanoyl-coa · ligand · chains A
TUT · 5-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	943	0.80	0.82	80	MYA, TUT, MG
2	152	0.43	0.74	17	empty
3	82	0.34	0.75	19	empty

Compared structures

5A27 · Leishmania major N-myristoyltransferase in complex with a chlorophenyl 1,2,4-oxadiazole… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4Q5S8
Elsewhere: RCSB PDB 5A27 · PDBe 5A27 · UniProt Q4Q5S8

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