MolNFT v1 · #112990 · protein
Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy
5A22 · Vesicular stomatitis virus L polymerase: “Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy”. Electron microscopy, 1 ligand (ZN), 20 pockets (best druggability 0.80). MolNFT v1 #112990 on…
- PDB
- 5A22
- Type
- protein
- Length
- 2,002 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vesicular stomatitis virus L polymerase
- EC
- 2.7.7.6
- UniProt
- P03523
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 48% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vesicular stomatitis virus L polymerase (EC 2.7.7.6) | protein | 2002 | 48% helix, 8% strand | P03523 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1178 | 0.80 | 0.81 | 101 | empty |
| 2 | 877 | 0.78 | 0.81 | 82 | empty |
| 3 | 397 | 0.75 | 0.85 | 43 | empty |
| 4 | 1061 | 0.75 | 0.78 | 112 | empty |
| 5 | 143 | 0.72 | 0.91 | 30 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03523
- Elsewhere: RCSB PDB 5A22 · PDBe 5A22 · UniProt P03523
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