Crystal structure of the mouse voltage gated calcium channel beta subunit isoform 1A in complex with alpha interaction domain peptide.

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 16% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains B
• NH2 · Amino group · ion · chains A, B
• PGE · Triethylene glycol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 833 Ų buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 4ZW2 · Crystal structure of the Mouse voltage gated calcium channel beta subunit isoform 1a in… · the same entry in another collection · chain A against A, TM-score 1.00
• Q8R3Z5 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.97
• Q02789 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.81

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8R3Z5
• Every structure of UniProt Q02789
• Elsewhere: RCSB PDB 4ZW2 · PDBe 4ZW2 · UniProt Q8R3Z5 · UniProt Q02789