MolNFT v1 · #11278 · protein

CA2+-binding mimicry in the crystal structure of the EU3+-bound mutant human macrophage capping protein cap G

1JHW: “CA2+-binding mimicry in the crystal structure of the EU3+-bound mutant human macrophage capping protein cap G”. X-ray diffraction, 1 ligand (EU3), 3 pockets (best druggability 0.43). MolNFT v1 #11278 on GenesisL1: 3D structure…

PDB: 1JHW
Type: protein
Length: 326 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrophage capping protein
UniProt: P40121
Ligands: EU3
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrophage capping protein	protein	326	21% helix, 29% strand	P40121

Ligands and binding sites

EU3 · Europium (III) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	157	0.43	0.75	26	empty
2	131	0.41	0.75	27	empty
3	73	0.30	0.74	17	empty

Compared structures

1JHW · Ca2+-binding Mimicry in the Crystal Structure of the Eu3+-Bound Mutant Human Macrophage… · the same entry in another collection · chain A against A, TM-score 1.00
P40121 · AlphaFold monomer V2.0 prediction for macrophage-capping protein (P40121) · a predicted model of the same protein · chain A against A, TM-score 0.34

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40121
Elsewhere: RCSB PDB 1JHW · PDBe 1JHW · UniProt P40121

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