MolNFT v1 · #112765 · protein
2.00 ångström resolution crystal structure of an uncharacterized protein from escherichia COLI O157:H7 str. sakai
4ZV9: “2.00 ångström resolution crystal structure of an uncharacterized protein from escherichia COLI O157:H7 str.…”. X-ray diffraction, 1 ligand (PO4), 17 pockets (best druggability 0.81). MolNFT v1 #112765 on GenesisL1: 3D structure…
- PDB
- 4ZV9
- Type
- protein
- Length
- 1,428 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- UniProt
- Q7AAT4
- Ligands
- PO4
- Pockets
- 17 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Uncharacterized protein | protein | 238 | 39% helix, 25% strand | Q7AAT4 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · chains B
- GOL · Glycerol · additive · 10 copies · chains A, F, B, D, E
- PGE · Triethylene glycol · additive · chains E, F
- PEG · Di(hydroxyethyl)ether · additive · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 407 | 0.81 | 0.89 | 49 | empty |
| 2 | 358 | 0.78 | 0.89 | 49 | empty |
| 3 | 1092 | 0.78 | 0.80 | 68 | empty |
| 4 | 399 | 0.77 | 0.87 | 49 | GOL |
| 5 | 344 | 0.56 | 0.75 | 35 | PGE |
Interfaces
5 interfaces between chains.
- C–D · 866 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 860 Ų buried · 16 hydrogen bonds · protein-protein
- B–E · 817 Ų buried · 10 hydrogen bonds · protein-protein
- A–F · 741 Ų buried · 8 hydrogen bonds · protein-protein
- E–F · 409 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered, artifact).
Compared structures
- 4ZV9 · 2.00 Angstrom resolution crystal structure of an uncharacterized protein from Escherichia… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7AAT4
- Elsewhere: RCSB PDB 4ZV9 · PDBe 4ZV9 · UniProt Q7AAT4
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