MolNFT v1 · #112688 · protein
Structure of a fusion protein with a helix linker, 2ARH-3-3KAW-2.0
4ZSX · Uncharacterized fusion protein: “Structure of a fusion protein with a helix linker, 2ARH-3-3KAW-2.0”. X-ray diffraction, 1 ligand (PO4), 5 pockets (best druggability 0.48). MolNFT v1 #112688 on GenesisL1: 3D structure, binding sites…
- PDB
- 4ZSX
- Type
- protein
- Length
- 587 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized fusion protein
- UniProt
- O67778, Q9I208
- Ligands
- PO4
- Pockets
- 5 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized fusion protein | protein | 293 | 55% helix, 17% strand | O67778, Q9I208 |
| B | Uncharacterized fusion protein | protein | 294 | 56% helix, 16% strand | O67778, Q9I208 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.48 | 0.82 | 17 | empty |
| 2 | 86 | 0.41 | 0.78 | 15 | empty |
| 3 | 55 | 0.35 | 0.79 | 11 | empty |
| 4 | 98 | 0.33 | 0.72 | 17 | empty |
| 5 | 76 | 0.30 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 845 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4ZSX · Structure of a fusion protein with a helix linker, 2ARH-3-3KAW-2.0 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67778
- Every structure of UniProt Q9I208
- Elsewhere: RCSB PDB 4ZSX · PDBe 4ZSX · UniProt O67778 · UniProt Q9I208
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