MolNFT v1 · #112572 · protein
Coxsackievirus B3 polymerase - F364I mutant
4ZP9 · RNA-dependent RNA polymerase: “Coxsackievirus B3 polymerase - F364I mutant”. X-ray diffraction, 2 pockets (best druggability 0.65). MolNFT v1 #112572 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ZP9
- Type
- protein
- Length
- 462 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-dependent RNA polymerase
- UniProt
- Q5UEA2
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-dependent RNA polymerase | protein | 462 | 42% helix, 15% strand | Q5UEA2 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 671 | 0.65 | 0.74 | 65 | empty |
| 2 | 363 | 0.60 | 0.76 | 39 | empty |
Compared structures
- 4ZP9 · Coxsackievirus B3 Polymerase - F364I mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5UEA2
- Elsewhere: RCSB PDB 4ZP9 · PDBe 4ZP9 · UniProt Q5UEA2
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