MolNFT v1 · #112570 · protein

Coxsackievirus B3 polymerase - F364V mutant

4ZP7 · Genome polyprotein: “Coxsackievirus B3 polymerase - F364V mutant”. X-ray diffraction, 3 pockets (best druggability 0.64). MolNFT v1 #112570 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ZP7
Type: protein
Length: 456 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: Q5UEA2
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein	protein	456	43% helix, 16% strand	Q5UEA2

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	621	0.64	0.74	61	empty
2	309	0.58	0.77	29	empty
3	61	0.29	0.74	14	empty

Compared structures

4ZP7 · Coxsackievirus B3 Polymerase - F364V mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5UEA2
Elsewhere: RCSB PDB 4ZP7 · PDBe 4ZP7 · UniProt Q5UEA2

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