MolNFT v1 · #112569 · protein

Coxsackievirus B3 polymerase - F364A mutant

4ZP6 · Genome polyprotein: “Coxsackievirus B3 polymerase - F364A mutant”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.57). MolNFT v1 #112569 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ZP6
Type: protein
Length: 454 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: Q5UEA2
Ligands: SO4
Pockets: 4 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein	protein	454	43% helix, 15% strand	Q5UEA2

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.57	0.75	34	SO4
2	291	0.56	0.77	27	empty
3	173	0.42	0.73	19	SO4
4	54	0.25	0.73	19	empty

Compared structures

4ZP6 · Coxsackievirus B3 Polymerase - F364A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5UEA2
Elsewhere: RCSB PDB 4ZP6 · PDBe 4ZP6 · UniProt Q5UEA2

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