MolNFT v1 · #112496 · protein
Crystal structure of MJSPT4:SPT5 complex conformation a
4ZN1 · Transcription elongation factor SPT5: “Crystal structure of MJSPT4:SPT5 complex conformation a”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.39). MolNFT v1 #112496 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4ZN1
- Type
- protein
- Length
- 197 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor SPT5; Transcription elongation factor SPT4
- UniProt
- Q57818, Q57839
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription elongation factor SPT5 | protein | 138 | 18% helix, 36% strand | Q57818 |
| B | Transcription elongation factor SPT4 | protein | 59 | 10% helix, 44% strand | Q57839 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.39 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 906 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4ZN1 · Crystal Structure of MjSpt4:Spt5 complex conformation A · the same entry in another collection · chain A against A, TM-score 1.00
- Q57839 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT4 (Q57839) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q57818 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT5 (Q57818) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q57818
- Every structure of UniProt Q57839
- Elsewhere: RCSB PDB 4ZN1 · PDBe 4ZN1 · UniProt Q57818 · UniProt Q57839
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.