MolNFT v1 · #112446 · protein

Crystal structure of transporter acrb triple mutant

4ZLL · Multidrug efflux pump subunit acrb: “Crystal structure of transporter acrb triple mutant”. X-ray diffraction, 15 pockets (best druggability 0.84). MolNFT v1 #112446 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ZLL
Type: protein
Length: 1,034 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multidrug efflux pump subunit acrb
UniProt: P31224
Pockets: 15 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multidrug efflux pump subunit acrb	protein	1034	49% helix, 17% strand	P31224

Pockets

15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1114	0.84	0.85	124	empty
2	301	0.70	0.84	37	empty
3	143	0.59	0.84	31	empty
4	185	0.59	0.80	28	empty
5	68	0.50	0.85	19	empty

Compared structures

4ZLL · Crystal structure of transporter AcrB triple mutant · the same entry in another collection · chain A against A, TM-score 1.00
P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31224
Elsewhere: RCSB PDB 4ZLL · PDBe 4ZLL · UniProt P31224

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