MolNFT v1 · #112320 · protein

Structure of HIV-1 rt Q151M mutant

4ZHR · Rt P66 subunit: “Structure of HIV-1 rt Q151M mutant”. X-ray diffraction, 14 pockets (best druggability 0.74). MolNFT v1 #112320 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ZHR
Type: protein
Length: 962 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rt P66 subunit; Rt P51 subunit
EC: 2.7.7.49, 2.7.7.7, 3.1.26.13
Pockets: 14 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rt P66 subunit (EC 2.7.7.49, 2.7.7.7, 3.1.26.13)	protein	553	32% helix, 24% strand	—
B	Rt P51 subunit (EC 2.7.7.49, 2.7.7.7)	protein	409	34% helix, 19% strand	—

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	492	0.74	0.83	43	empty
2	597	0.72	0.79	45	empty
3	668	0.71	0.78	63	empty
4	616	0.71	0.78	59	empty
5	469	0.63	0.76	65	empty

Interfaces

1 interface between chains.

A–B · 2858 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

4ZHR · Structure of HIV-1 RT Q151M mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4ZHR · PDBe 4ZHR

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