MolNFT v1 · #112220 · protein

Crystal structure of EIF2B delta from chaetomium thermophilum

4ZEO · Translation initiation factor eif-2B-like protein: “Crystal structure of EIF2B delta from chaetomium thermophilum”. X-ray diffraction, 5 pockets (best druggability 0.73). MolNFT v1 #112220 on GenesisL1: 3D structure, binding sites…

PDB: 4ZEO
Type: protein
Length: 543 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translation initiation factor eif-2B-like protein
UniProt: G0S811
Pockets: 5 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 53% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Translation initiation factor eif-2B-like protein	protein	273	53% helix, 14% strand	G0S811
A	Translation initiation factor eif-2B-like protein	protein	270	53% helix, 14% strand	G0S811

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	956	0.73	0.76	87	empty
2	207	0.61	0.82	28	empty
3	213	0.59	0.81	25	empty
4	81	0.43	0.79	14	empty
5	51	0.36	0.79	15	empty

Interfaces

1 interface between chains.

H–A · 772 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

4ZEO · Crystal structure of eIF2B delta from Chaetomium thermophilum · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S811
Elsewhere: RCSB PDB 4ZEO · PDBe 4ZEO · UniProt G0S811

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