MolNFT v1 · #11220 · protein
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, gfrp
1JG5: “Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, gfrp”. X-ray diffraction, 1 ligand (K), 3 pockets (best druggability 0.54). MolNFT v1 #11220 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1JG5
- Type
- protein
- Length
- 415 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP cyclohydrolase I feedback regulatory protein
- UniProt
- P70552
- Ligands
- K
- Pockets
- 3 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 19% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | GTP cyclohydrolase I feedback regulatory protein | protein | 83 | 19% helix, 40% strand | P70552 |
Ligands and binding sites
- K · Potassium ion · metal · 5 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.54 | 0.78 | 34 | empty |
| 2 | 84 | 0.40 | 0.78 | 20 | empty |
| 3 | 52 | 0.34 | 0.79 | 19 | K |
Interfaces
5 interfaces between chains.
- A–B · 1010 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 999 Ų buried · 14 hydrogen bonds · protein-protein
- A–E · 990 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 990 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 985 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1JG5 · Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, gfrp · the same entry in another collection · chain A against A, TM-score 1.00
- P70552 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 feedback regulatory protein… · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70552
- Elsewhere: RCSB PDB 1JG5 · PDBe 1JG5 · UniProt P70552
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