MolNFT v1 · #111994 · protein + RNA

Crystal structure of CRISPR RNA processing endoribonuclease CAS6B

4Z7K: “Crystal structure of CRISPR RNA processing endoribonuclease CAS6B”. X-ray diffraction, 6 pockets (best druggability 0.74). MolNFT v1 #111994 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4Z7K
Type: protein + RNA
Length: 438 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CAS6B; RNA/DNA hybrid (31-mer)
UniProt: A4FXZ3
Pockets: 6 · best druggability 0.74

Structure

x-ray diffraction · 3 distinct chains · 27% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	CAS6B	protein	195	29% helix, 35% strand	A4FXZ3
A	CAS6B	protein	218	25% helix, 35% strand	A4FXZ3
C	RNA/DNA hybrid (31-mer)	rna	25	—	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	699	0.74	0.80	64	empty
2	309	0.58	0.77	33	empty
3	72	0.46	0.81	13	empty
4	56	0.36	0.79	12	empty
5	87	0.35	0.75	15	empty

Interfaces

3 interfaces between chains.

A–C · 1867 Å² buried · 50 hydrogen bonds · protein-nucleic
B–C · 965 Å² buried · 22 hydrogen bonds · protein-nucleic
B–A · 235 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4Z7K · Crystal structure of CRISPR RNA processing endoribonuclease Cas6b · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A4FXZ3
Elsewhere: RCSB PDB 4Z7K · PDBe 4Z7K · UniProt A4FXZ3

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