MolNFT v1 · #111906 · protein

Crystal structure of GFP-TAX1BP1 UBZ1+2 domain fusion protein

4Z4K · Green fluorescent PROTEIN,TAX1-binding protein 1: “Crystal structure of GFP-TAX1BP1 UBZ1+2 domain fusion protein”. X-ray diffraction, 2 ligands (CR2, ZN), 9 pockets (best druggability 0.76). MolNFT v1 #111906 on GenesisL1: 3D…

PDB: 4Z4K
Type: protein
Length: 563 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Green fluorescent PROTEIN,TAX1-binding protein 1
UniProt: P42212, Q86VP1
Ligands: CR2, ZN
Pockets: 9 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 14% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Green fluorescent PROTEIN,TAX1-binding protein 1	protein	282	14% helix, 44% strand	P42212, Q86VP1
B	Green fluorescent PROTEIN,TAX1-binding protein 1	protein	281	14% helix, 45% strand	P42212, Q86VP1

Ligands and binding sites

CR2 · {(4Z)-2-(aminomethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · 2 copies · chains A, B
ZN · Zinc ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	705	0.76	0.81	77	empty
2	54	0.71	0.98	19	CR2
3	277	0.56	0.77	39	empty
4	122	0.46	0.78	22	empty
5	77	0.40	0.79	17	empty

Interfaces

1 interface between chains.

A–B · 1258 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 cofactor (chromophore).

Compared structures

4Z4K · Crystal structure of GFP-TAX1BP1 UBZ1+2 domain fusion protein · the same entry in another collection · chain A against A, TM-score 1.00
P42212 · AlphaFold monomer V2.0 prediction for green fluorescent protein (P42212) · a predicted model of the same protein · chain A against A, TM-score 0.79
Q86VP1 · AlphaFold monomer V2.0 prediction for TAX1-binding protein 1 (Q86VP1) · a predicted model of the same protein · chain B against A, TM-score 0.23

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42212
Every structure of UniProt Q86VP1
Elsewhere: RCSB PDB 4Z4K · PDBe 4Z4K · UniProt P42212 · UniProt Q86VP1

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