MolNFT v1 · #111778 · protein
Structure of hepatitis C virus envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM
4Z0X · Antibody HC26AM light chain variable domain: “Structure of hepatitis C virus envelope glycoprotein E2 antigenic region 434-446 bound to the broadly…”. X-ray diffraction, 1 pocket (best druggability 0.28). MolNFT v1 #111778 on…
- PDB
- 4Z0X
- Type
- protein
- Length
- 218 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody HC26AM light chain variable domain; Antibody HC26AM heavy chain variable domain…
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody HC26AM light chain variable domain | protein | 105 | 6% helix, 50% strand | — |
| B | Antibody HC26AM heavy chain variable domain | protein | 101 | 3% helix, 54% strand | — |
| C | HCV E2 antigen (residues 432-446) | protein | 12 | 58% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.28 | 0.74 | 11 | empty |
Interfaces
3 interfaces between chains.
- A–B · 751 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 393 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 356 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4Z0X · Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4Z0X · PDBe 4Z0X
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