MolNFT v1 · #111775 · protein

RNase HI/SSB-ct complex

4Z0U · Ribonuclease H: “RNase HI/SSB-ct complex”. X-ray diffraction, 1 pocket (best druggability 0.70). MolNFT v1 #111775 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4Z0U
Type: protein
Length: 318 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease H; Ssb-ct peptide
EC: 3.1.26.4
UniProt: A7ZHV1
Pockets: 1 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ribonuclease H (EC 3.1.26.4)	protein	155	36% helix, 31% strand	A7ZHV1
D, E	Ssb-ct peptide	protein	4	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	721	0.70	0.77	63	empty

Interfaces

3 interfaces between chains.

A–B · 747 Å² buried · 11 hydrogen bonds · protein-protein
B–E · 404 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 377 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4Z0U · RNase HI/SSB-Ct complex · the same entry in another collection · chain A against A, TM-score 1.00
A7ZHV1 · AlphaFold monomer V2.0 prediction for ribonuclease H (A7ZHV1) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A7ZHV1
Elsewhere: RCSB PDB 4Z0U · PDBe 4Z0U · UniProt A7ZHV1

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