MolNFT v1 · #111764 · protein
F96S/S73A double mutant of plasmodium falciparum triosephosphate isomerase
4Z0J: “F96S/S73A double mutant of plasmodium falciparum triosephosphate isomerase”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.80). MolNFT v1 #111764 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4Z0J
- Type
- protein
- Length
- 491 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Triosephosphate isomerase
- EC
- 5.3.1.1
- UniProt
- Q07412
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Triosephosphate isomerase (EC 5.3.1.1) | protein | 244 | 43% helix, 17% strand | Q07412 |
| B | Triosephosphate isomerase (EC 5.3.1.1) | protein | 247 | 44% helix, 15% strand | Q07412 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 12 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.80 | 0.94 | 41 | SO4 |
| 2 | 158 | 0.48 | 0.77 | 29 | SO4 |
| 3 | 173 | 0.46 | 0.76 | 41 | EDO |
Interfaces
1 interface between chains.
- A–B · 1707 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 4Z0J · F96S/S73A Double mutant of Plasmodium Falciparum Triosephosphate Isomerase · the same entry in another collection · chain A against A, TM-score 1.00
- Q07412 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase (Q07412) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07412
- Elsewhere: RCSB PDB 4Z0J · PDBe 4Z0J · UniProt Q07412
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