MolNFT v1 · #111760 · protein

Crystal structure of fvo strain plasmodium falciparum AMA1 in complex with the RON2HP [PHE2038(6CW)] peptide

4Z0F · Apical membrane antigen 1: “Crystal structure of fvo strain plasmodium falciparum AMA1 in complex with the RON2HP [PHE2038(6CW)] peptide”. X-ray diffraction, 1 pocket (best druggability 0.27). MolNFT v1 #111760 on GenesisL1: 3D…

PDB: 4Z0F
Type: protein
Length: 291 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apical membrane antigen 1; Rhoptry neck protein 2
UniProt: A0A024UZE1
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apical membrane antigen 1	protein	278	16% helix, 31% strand	A0A024UZE1
C	Rhoptry neck protein 2	protein	13	0% helix, 38% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.27	0.72	14	empty

Interfaces

1 interface between chains.

A–C · 680 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 1 modified (disulfide, nonstandard).

Compared structures

4Z0F · Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A024UZE1
Elsewhere: RCSB PDB 4Z0F · PDBe 4Z0F · UniProt A0A024UZE1

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