MolNFT v1 · #111746 · protein

Crystal structures reveal transient perk luminal domain tetramerization in er stress signaling

4YZY · Eukaryotic translation initiation factor 2-alpha kinase 3: “Crystal structures reveal transient perk luminal domain tetramerization in er stress signaling”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #111746 on…

PDB: 4YZY
Type: protein
Length: 163 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eukaryotic translation initiation factor 2-alpha kinase 3
EC: 2.7.11.1
UniProt: Q9Z2B5
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1)	protein	163	0% helix, 48% strand	Q9Z2B5

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.35	0.76	17	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4YZY · Crystal structures reveal transient PERK luminal domain tetramerization in ER stress… · the same entry in another collection · chain A against A, TM-score 1.00
Q9Z2B5 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2-alpha… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Z2B5
Elsewhere: RCSB PDB 4YZY · PDBe 4YZY · UniProt Q9Z2B5

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