MolNFT v1 · #111704 · protein
FICIN A
4YYQ · Ficin isoform a: “FICIN A”. X-ray diffraction, 2 pockets (best druggability 0.71). MolNFT v1 #111704 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YYQ
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ficin isoform a
- EC
- 3.4.22.3
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ficin isoform a (EC 3.4.22.3) | protein | 216 | 28% helix, 23% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 506 | 0.71 | 0.80 | 57 | empty |
| 2 | 104 | 0.44 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 473 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 modified (disulfide, methylation).
Compared structures
- 4YYQ · Ficin A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4YYQ · PDBe 4YYQ
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