MolNFT v1 · #111667 · protein
The structure of the folded domain of the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.
4YXP · MRNA export factor: “The structure of the folded domain of the signature multifunctional protein ICP27 from herpes simplex virus-1…”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.72). MolNFT v1 #111667 on…
- PDB
- 4YXP
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA export factor
- UniProt
- P10238
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MRNA export factor | protein | 268 | 63% helix, 1% strand | P10238 |
| B | MRNA export factor | protein | 271 | 62% helix, 1% strand | P10238 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 964 | 0.72 | 0.76 | 80 | empty |
| 2 | 53 | 0.53 | 0.88 | 15 | empty |
| 3 | 163 | 0.52 | 0.79 | 35 | empty |
| 4 | 86 | 0.36 | 0.75 | 18 | empty |
| 5 | 77 | 0.35 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 5527 Ų buried · 62 hydrogen bonds · protein-protein
Compared structures
- 4YXP · The structure of the folded domain of the signature multifunctional protein ICP27 from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10238
- Elsewhere: RCSB PDB 4YXP · PDBe 4YXP · UniProt P10238
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