MolNFT v1 · #111641 · protein
Thermostable enolase from chloroflexus aurantiacus
4YWS: “Thermostable enolase from chloroflexus aurantiacus”. X-ray diffraction, 1 ligand (MG), 9 pockets (best druggability 0.74). MolNFT v1 #111641 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YWS
- Type
- protein
- Length
- 798 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enolase
- EC
- 4.2.1.11
- UniProt
- A9WCM4
- Ligands
- MG
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Enolase (EC 4.2.1.11) | protein | 405 | 43% helix, 18% strand | A9WCM4 |
| B | Enolase (EC 4.2.1.11) | protein | 393 | 43% helix, 19% strand | A9WCM4 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1027 | 0.74 | 0.77 | 53 | empty |
| 2 | 90 | 0.73 | 0.96 | 23 | empty |
| 3 | 821 | 0.70 | 0.76 | 72 | MG |
| 4 | 271 | 0.62 | 0.81 | 33 | MG |
| 5 | 68 | 0.40 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1636 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A9WCM4
- Elsewhere: RCSB PDB 4YWS · PDBe 4YWS · UniProt A9WCM4
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