MolNFT v1 · #111557 · protein
Crystal structure of human nicotinic acid phosphoribosyltransferase
4YUB · Nicotinate phosphoribosyltransferase: “Crystal structure of human nicotinic acid phosphoribosyltransferase”. X-ray diffraction, 17 pockets (best druggability 0.84). MolNFT v1 #111557 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4YUB
- Type
- protein
- Length
- 1,001 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nicotinate phosphoribosyltransferase
- EC
- 6.3.4.21
- UniProt
- Q6XQN6
- Pockets
- 17 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicotinate phosphoribosyltransferase (EC 6.3.4.21) | protein | 500 | 38% helix, 19% strand | Q6XQN6 |
| B | Nicotinate phosphoribosyltransferase (EC 6.3.4.21) | protein | 501 | 36% helix, 18% strand | Q6XQN6 |
Pockets
17 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1197 | 0.84 | 0.85 | 101 | empty |
| 2 | 251 | 0.76 | 0.89 | 36 | empty |
| 3 | 103 | 0.65 | 0.89 | 22 | empty |
| 4 | 231 | 0.53 | 0.76 | 28 | empty |
| 5 | 165 | 0.52 | 0.79 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 1389 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4YUB · Crystal structure of human Nicotinic Acid Phosphoribosyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
- Q6XQN6 · AlphaFold monomer V2.0 prediction for nicotinate phosphoribosyltransferase (Q6XQN6) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6XQN6
- Elsewhere: RCSB PDB 4YUB · PDBe 4YUB · UniProt Q6XQN6
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