MolNFT v1 · #1115 · protein

T7 RNA polymerase complexed with T7 lysozyme

1ARO: “T7 RNA polymerase complexed with T7 lysozyme”. X-ray diffraction, 1 ligand (HG), 14 pockets (best druggability 0.81). MolNFT v1 #1115 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ARO
Type: protein
Length: 923 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T7 RNA polymerase; T7 lysozyme
EC: 2.7.7.6, 3.5.1.28
UniProt: P00573, P00806
Ligands: HG
Pockets: 14 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
P	T7 RNA polymerase (EC 2.7.7.6)	protein	774	49% helix, 7% strand	P00573
L	T7 lysozyme (EC 3.5.1.28)	protein	149	26% helix, 19% strand	P00806

Ligands and binding sites

HG · Mercury (II) ion · metal · 7 copies · chains P, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1042	0.81	0.82	97	HG
2	74	0.68	0.93	16	empty
3	614	0.68	0.77	44	HG
4	325	0.62	0.79	42	empty
5	240	0.57	0.78	39	empty

Interfaces

1 interface between chains.

P–L · 1134 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

1ARO · T7 RNA polymerase complexed with T7 lysozyme · the same entry in another collection · chain P against P, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00573
Every structure of UniProt P00806
Elsewhere: RCSB PDB 1ARO · PDBe 1ARO · UniProt P00573 · UniProt P00806

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