MolNFT v1 · #111426 · protein
Crystal structure of trmd, a M1G37 tRNA methyltransferase with SAM- competitive compounds
4YQJ · TRNA (guanine-N(1)-)-methyltransferase: “Crystal structure of trmd, a M1G37 tRNA methyltransferase with SAM- competitive compounds”. X-ray diffraction, 1 ligand (4GT), 1 pocket (best druggability 0.53). MolNFT v1 #111426 on…
- PDB
- 4YQJ
- Type
- protein
- Length
- 237 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (guanine-N(1)-)-methyltransferase
- EC
- 2.1.1.228
- UniProt
- P43912
- Ligands
- 4GT
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.228) | protein | 237 | 43% helix, 17% strand | P43912 |
Ligands and binding sites
- 4GT · 4-amino-2-(cyclopentylamino)pyrimidine-5-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.53 | 0.83 | 21 | 4GT |
Compared structures
- 4YQJ · Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds · the same entry in another collection · chain A against A, TM-score 1.00
- P43912 · AlphaFold monomer V2.0 prediction for tRNA (guanine-N(1)-)-methyltransferase (P43912) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43912
- Elsewhere: RCSB PDB 4YQJ · PDBe 4YQJ · UniProt P43912
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