MolNFT v1 · #111339 · protein
Structure of the N-terminal domain of sad
4YNZ · SERINE/THREONINE-protein kinase BRSK2: “Structure of the N-terminal domain of sad”. X-ray diffraction, 8 pockets (best druggability 0.85). MolNFT v1 #111339 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YNZ
- Type
- protein
- Length
- 636 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase BRSK2
- EC
- 2.7.11.26
- UniProt
- Q69Z98
- Pockets
- 8 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase BRSK2 (EC 2.7.11.26) | protein | 313 | 43% helix, 15% strand | Q69Z98 |
| B | SERINE/THREONINE-protein kinase BRSK2 (EC 2.7.11.26) | protein | 323 | 42% helix, 15% strand | Q69Z98 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 978 | 0.85 | 0.86 | 93 | empty |
| 2 | 596 | 0.72 | 0.80 | 37 | empty |
| 3 | 429 | 0.69 | 0.80 | 35 | empty |
| 4 | 135 | 0.50 | 0.80 | 24 | empty |
| 5 | 100 | 0.43 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1168 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q69Z98
- Elsewhere: RCSB PDB 4YNZ · PDBe 4YNZ · UniProt Q69Z98
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