MolNFT v1 · #111245 · protein

Crystal structure of truncated cerebral cavernous malformation 2 C- terminal adaptor domain in complex with an internal helix of mitogen- activated protein kinase kinase kinase 3

4YL6 · Malcavernin: “Crystal structure of truncated cerebral cavernous malformation 2 C- terminal adaptor domain in complex with…”. X-ray diffraction. MolNFT v1 #111245 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4YL6
Type: protein
Length: 106 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Malcavernin; Mitogen-activated protein kinase kinase kinase 3
UniProt: Q9BSQ5, Q99759

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Malcavernin	protein	88	75% helix, 0% strand	Q9BSQ5
B	Mitogen-activated protein kinase kinase kinase 3	protein	18	89% helix, 0% strand	Q99759

Interfaces

1 interface between chains.

A–B · 908 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4YL6 · Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor… · the same entry in another collection · chain A against A, TM-score 1.00
Q9BSQ5 · AlphaFold monomer V2.0 prediction for cerebral cavernous malformations 2 protein (Q9BSQ5) · a predicted model of the same protein · chain A against A, TM-score 0.86
Q99759 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 3… · a predicted model of the same protein · chain B against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BSQ5
Every structure of UniProt Q99759
Elsewhere: RCSB PDB 4YL6 · PDBe 4YL6 · UniProt Q9BSQ5 · UniProt Q99759

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