MolNFT v1 · #111058 · protein

Crystal structure of ptp delta FN1-FN2

4YFE · Receptor-type tyrosine-protein phosphatase delta: “Crystal structure of ptp delta FN1-FN2”. X-ray diffraction, 1 pocket (best druggability 0.27). MolNFT v1 #111058 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4YFE
Type: protein
Length: 386 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase delta
EC: 3.1.3.48
UniProt: Q64487
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Receptor-type tyrosine-protein phosphatase delta (EC 3.1.3.48)	protein	193	2% helix, 46% strand	Q64487

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.27	0.73	16	empty

Interfaces

1 interface between chains.

A–B · 179 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4YFE · Crystal structure of PTP delta Fn1-Fn2 · the same entry in another collection · chain A against A, TM-score 1.00
Q64487 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase delta… · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64487
Elsewhere: RCSB PDB 4YFE · PDBe 4YFE · UniProt Q64487

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