MolNFT v1 · #111047 · protein + DNA
HUAA-20BP
4YEY · DNA-binding protein hu-alpha: “HUAA-20BP”. X-ray diffraction, 1 pocket (best druggability 0.51). MolNFT v1 #111047 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YEY
- Type
- protein + DNA
- Length
- 176 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-binding protein hu-alpha; Synthetic DNA strand
- UniProt
- P0ACF2
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-binding protein hu-alpha | protein | 73 | 52% helix, 23% strand | P0ACF2 |
| B | Synthetic DNA strand | dna | 15 | — | — |
| D | Synthetic DNA strand | dna | 15 | — | — |
| C | DNA-binding protein hu-alpha | protein | 73 | 52% helix, 23% strand | P0ACF2 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 227 | 0.51 | 0.76 | 18 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1982 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 613 Ų buried · 28 hydrogen bonds · nucleic-nucleic
- B–C · 141 Ų buried · 3 hydrogen bonds · protein-nucleic
- D–C · 123 Ų buried · 2 hydrogen bonds · protein-nucleic
- A–D · 42 Ų buried · 0 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACF2
- Elsewhere: RCSB PDB 4YEY · PDBe 4YEY · UniProt P0ACF2
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