MolNFT v1 · #111046 · protein + DNA
HUAA-19BP
4YEX · DNA-binding protein hu-alpha: “HUAA-19BP”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #111046 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YEX
- Type
- protein + DNA
- Length
- 171 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-binding protein hu-alpha; Synthetic DNA strand
- UniProt
- P0ACF2
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 4 distinct chains · 54% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-binding protein hu-alpha | protein | 70 | 54% helix, 23% strand | P0ACF2 |
| B | Synthetic DNA strand | dna | 15 | — | — |
| D | Synthetic DNA strand | dna | 15 | — | — |
| C | DNA-binding protein hu-alpha | protein | 71 | 54% helix, 23% strand | P0ACF2 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.55 | 0.77 | 18 | empty |
| 2 | 52 | 0.27 | 0.74 | 14 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1907 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 606 Ų buried · 34 hydrogen bonds · nucleic-nucleic
- D–C · 133 Ų buried · 2 hydrogen bonds · protein-nucleic
- B–C · 120 Ų buried · 1 hydrogen bond · protein-nucleic
- A–D · 42 Ų buried · 0 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACF2
- Elsewhere: RCSB PDB 4YEX · PDBe 4YEX · UniProt P0ACF2
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