MolNFT v1 · #111045 · protein + DNA
HUAB-19BP
4YEW · DNA-binding protein hu-beta: “HUAB-19BP”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #111045 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YEW
- Type
- protein + DNA
- Length
- 162 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-binding protein hu-beta; Synthetic DNA strand; DNA-binding protein hu-alpha
- UniProt
- N4NVB4, P0ACF2
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-binding protein hu-beta | protein | 71 | 51% helix, 23% strand | N4NVB4 |
| B | Synthetic DNA strand | dna | 9 | — | — |
| D | Synthetic DNA strand | dna | 11 | — | — |
| C | DNA-binding protein hu-alpha | protein | 71 | 54% helix, 23% strand | P0ACF2 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 267 | 0.47 | 0.73 | 26 | empty |
| 2 | 76 | 0.29 | 0.73 | 10 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1886 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 430 Ų buried · 37 hydrogen bonds · nucleic-nucleic
- D–C · 248 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt N4NVB4
- Every structure of UniProt P0ACF2
- Elsewhere: RCSB PDB 4YEW · PDBe 4YEW · UniProt N4NVB4 · UniProt P0ACF2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.