MolNFT v1 · #111039 · protein
L4B domain of human laminin alpha-2
4YEP · Laminin subunit alpha-2: “L4B domain of human laminin alpha-2”. X-ray diffraction, 4 pockets (best druggability 0.65). MolNFT v1 #111039 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YEP
- Type
- protein
- Length
- 370 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Laminin subunit alpha-2
- UniProt
- P24043
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 14% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Laminin subunit alpha-2 | protein | 185 | 14% helix, 40% strand | P24043 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 15 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 277 | 0.65 | 0.82 | 39 | EDO |
| 2 | 130 | 0.49 | 0.79 | 21 | EDO |
| 3 | 112 | 0.39 | 0.75 | 20 | empty |
| 4 | 61 | 0.34 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 499 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4YEP · L4b Domain of Human Laminin alpha-2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24043
- Elsewhere: RCSB PDB 4YEP · PDBe 4YEP · UniProt P24043
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